A standard annual physical misses most of the markers that research associates with longevity. Here is what a comprehensive longevity panel includes and why each marker matters.
Quick Summary The standard annual blood panel covers roughly 15-20 markers. Research on longevity identifies 40+ markers that provide meaningful predictive information. This article covers the comprehensive longevity panel -- what it includes, why each marker matters, and how to track trends. Educational purposes only -- not medical advice.
A typical annual physical includes a CBC, basic metabolic panel, lipid panel, and perhaps a TSH. This covers acute disease detection but misses most of what research associates with long-term health trajectory.
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Cardiovascular Risk: ApoB, Lp(a), hs-CRP, Homocysteine, Omega-3 Index
Metabolic Health: Fasting glucose, Fasting insulin, HbA1c, HOMA-IR, Uric acid
Hormonal Health: Total and Free testosterone, SHBG, Estradiol, DHEA-S, IGF-1, TSH/Free T3/Free T4
Nutrient Status: 25-OH Vitamin D, RBC Magnesium, Zinc, Ferritin, B12, Folate
Organ Function: ALT, AST, GGT, Creatinine, BUN, eGFR
Inflammation: hs-CRP, Fibrinogen, WBC differential
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These are educational reference points from published research -- not clinical recommendations.
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Function Health, Quest Diagnostics, LabCorp, Cleveland HeartLab, Boston Heart Diagnostics, and Marek Health all offer comprehensive panels compatible with [MyProtocolStack lab tracking](https://myprotocolstack.com/labs).
How often should I get a longevity panel?
Research protocols recommend quarterly for people actively optimizing, and annually as a baseline for otherwise healthy individuals.
Is a longevity panel covered by insurance?
Standard components are often covered. Advanced markers like ApoB, Lp(a), and fasting insulin typically require out-of-pocket payment.
What is the most important marker in a longevity panel?
Patterns across the full panel are more informative than any single value. ApoB, fasting insulin, and hs-CRP are among the most predictive in published epidemiological studies.
At what age should I start a comprehensive longevity panel?
Research supports starting early to establish baselines. Some practitioners recommend comprehensive baselines in the late 20s or early 30s.
What is HOMA-IR and why does it matter?
HOMA-IR is calculated from fasting glucose and fasting insulin. Research shows it is one of the most sensitive early markers of metabolic dysfunction.
*This article is for educational purposes only. Consult a licensed healthcare provider to determine which tests are appropriate for your situation.*
*Written by the MyProtocolStack team. Last updated: March 2026.*
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